Roger Federer eased to a 6-3 7-5 6-4 win over Brazilian Thiago Alves to book his place in the US Open third round.
The defending champion was never at his best, committing 46 unforced errors and converting only four of his 15 break points against the qualifier.
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Djokovic powers into last eight ... - and the crowd - by breaking back in the third set to draw level at 3-3.
But the world number two found his form at 4-4 to break once more before effortlessly serving out victory.
Federer will face 28th seed Radek Stepanek or Chris Guccione in the third round.
He remains on course for a quarter-final meeting with fifth seed Nikolay Davydenko, who kept up his serene progress in New York with a 6-4 6-4 7-6 win over Argentine Agustin Calleri.
Davydenko will meet fellow Russian Dmitry Tursunov in the third round.
In the same quarter of the draw, Luxembourg's Gilles Muller caused a surprise by recovering from two sets down to beat Tommy Haas.
Muller reached the third round of a Grand Slam for only the second time his career - and the first time in New York - after a 2-6 2-6 7-6 (7-5) 6-3 6-3 win.
Fernando Gonzalez survived an injury scare before getting the better of American Bobby Reynolds.
The Chilean, seeded 11th, needed treatment after turning his ankle in his 7-6 (8-6) 6-4 6-4 win.
Gonzalez meets Finland's Jarkko Nieminen in the last 32.
(BBC)
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